A technique for stable adhesion of DNA to a modified graphite surface for imaging by scanning tunneling microscopy
作者:
Yuri L. Lyubchenko,
S. M. Lindsay,
J. A. DeRose,
T. Thundat,
期刊:
Journal of Vacuum Science&Technology B: Microelectronics and Nanometer Structures Processing, Measurement, and Phenomena
(AIP Available online 1991)
卷期:
Volume 9,
issue 2
页码: 1288-1290
ISSN:1071-1023
年代: 1991
DOI:10.1116/1.585223
出版商: American Vacuum Society
关键词: SCANNING ELECTRON MICROSCOPY;USES;DNA;ADHESION;MERCURY;SAMPLE PREPARATION;AQUEOUS SOLUTIONS;GRAPHITE
数据来源: AIP
摘要:
A procedure has been developed in which mercurated DNA is covalently bonded to a modified graphite surface. This technique allows for stable adhesion of the DNA which enables one to image it with the scanning tunneling microscope. The method is outlined in this paper and images are presented of a partially modified graphite surface and one completely modified with DNA attached. The DNA images demonstrate B‐helix periodicity.
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