Experimental Hypertension in Young and Adult Animals
作者:
JOSEF ZICHA,
JAROSLAV KUNEŠ,
JiŘí JELÍNEK,
期刊:
Hypertension
(OVID Available online 1986)
卷期:
Volume 8,
issue 12
页码: 1096-1104
ISSN:0194-911X
年代: 1986
出版商: OVID
关键词: ontogenesis;age-dependent susceptibility;salt hypertension;electrolyte metabolism;body fluids;natriuretic factors;vasoactive systems;hemodynamics
数据来源: OVID
摘要:
The susceptibility of immature and adult animals to various environmental factors often differs because the response of the young organism can only involve those regulatory mechanisms that are available at the particular stage of development. Increased sensitivity to certain (e.g., hypertensive) stimuli may be limited to a relatively short age period that is usually characterized by the maturation of some, important physiological functions. High salt intake seems to influence the animals especially during the weaning period and prepuberty, in the course of which profound developmental changes of circulation, electrolyte metabolism, and neurohumoral regulation have been demonstrated. Indeed, salt-dependent forms of experimental hypertension are more severe when they are induced in immature animals. Moreover, substantial differences in hemodynamics, distribution of body fluids, and involvement of pressor and natriuretic agents indicate that the mechanisms of salt hypertension need not be the same in immature and adult animals. For this reason, increased attention should be paid to developmental factors in the study of induced forms of experimental hypertension.
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