Twenty-Four-Hour Secretory Pattern of Vasoactive Intestinal Polypeptide in the Elderly
作者:
Ermanno Rolandi,
Roberto Franceschini,
Angelo Cataldi,
Tommaso Barreca,
期刊:
Gerontology
(Karger Available online 1990)
卷期:
Volume 36,
issue 5-6
页码: 356-360
ISSN:0304-324X
年代: 1990
DOI:10.1159/000213221
出版商: S. Karger AG
关键词: Elderly men;Plasma vasoactive intestinal polypeptide;Twenty-four-hour secretory pattern
数据来源: Karger
摘要:
A chronobiological study was carried out in 8 elderly male subjects (74–85 years) to evaluate the 24-hour vasoactive intestinal polypeptide (VIP) secretory pattern. Eight young adult males (21–32 years) made up the control group. Blood samples were drawn from each subject every 2 h during the day and hourly during the night for a 24-hour period. Mean 24-hour VIP values in elderly (21.1 ± 0.3 pg/ml) and young adults (19.1 ± 0.3 pg/ml) did not differ statistically, but daytime VIP values observed in elderly subjects (21.4 ± 0.5 pg/ml) were higher (p < 0.05) than those recorded in young adults (17.5 ± 0.5 pg/ml). The young adults showed significant (p < 0.05) circadian VIP fluctuations with highest values during the nighttime, while the elderly subjects did not. An age-related decreased activity of the peripheral neuronal VIP-ergic network is hypot
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