Survival of Oral Human Immune Serum Globulin in the Gastrointestinal Tract of Low Birth Weight Infants
作者:
PAUL BLUM,
DALE PHELPS,
BONNIE ANK,
HERBERT KRANTMAN,
E. STIEHM,
期刊:
Pediatric Research
(OVID Available online 1981)
卷期:
Volume 15,
issue 9
页码: 1256-1260
ISSN:0031-3998
年代: 1981
出版商: OVID
关键词: coproantibodies human immune globulin IgG;intestinal immunity opsonin
数据来源: OVID
摘要:
SummarySix immature infants were given oral feedings of 10% preservative-free human immune serum globulin ranging from 1 to 8 ml/kg/day. A seventh infant served as a control. Undigested and partially digested IgG was detected in the stools in significant quantities in all but the control infant. This coproantibody retained significant opsonic activity for type III group B streptococci as determined by a chemiluminescence assay, but lost most of its tetanus antibody activity. The newborn infants' enzymatic immaturity or rapid transit time permits the passage of intact IgG or partially digested IgG to pass throughout the gastrointestinal tract.
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