Electrophysiologic deficits in peripheral nerve as a discriminator of early hexacarbon neurotoxicity
作者:
R. J. Anderson,
C. B. Dunham,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1984)
卷期:
Volume 13,
issue 4-6
页码: 835-843
ISSN:0098-4108
年代: 1984
DOI:10.1080/15287398409530544
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
To determine the extent of neurotoxicity of parenterally administered hexacarbons, male Sprague‐Dawley rats were given eithern‐hexane or 2,5‐hexanedione for 35 consecutive days. Electrophysiologic measurements showed a lengthening of the sciatic and sural nerve action potentials (slower conduction velocities) and increased refractory periods. These effects correlated with a shift in the nerve membrane sensitivity to potassium‐induced depolarization. A similar effect can be induced by ouabain, an Na+, K+A TPase inhibitor. These effects were seen with bothn‐hexane and 2,5‐hexanedione. Although the treated animals gained wieght more slowly than controls, they showed no loss of motor function when tested behaviorally, and there were no signs of histopathology in the peripheral nerves. These results show that hexacarbons produce a neurotoxocity that can be demonstrated by changes in nerve excitability, prior to overt behavioral neurotoxocity. Furthermore, these electrophysiologic changes may be related to a hexacarbon‐induced disruption of nerve‐membrane A TPase activity.
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