Airway Function in Sarcoidosis: Smokers versus Nonsmokers
作者:
R.E. Dutton,
P.M. Renzi,
V. Lopez-Majano,
G.D. Renzi,
期刊:
Respiration
(Karger Available online 1982)
卷期:
Volume 43,
issue 3
页码: 164-173
ISSN:0025-7931
年代: 1982
DOI:10.1159/000194481
出版商: S. Karger AG
关键词: Pulmonary sarcoidosis;Obstructive lung disease;Smokers and sarcoidosis
数据来源: Karger
摘要:
Pulmonary function was measured in 24 sarcoidosis patients, 17 nonsmokers and 7 smokers. 12 (4 smokers) had evidence of small airway disease and 6 patients (3 smokers) had evidence of large airway disease. A significantly greater proportion of smokers had an increased closing volume, and closing volume appears to be the most sensitive test for small airway disease in sarcoidosis. However, 3 patients with normal closing volumes had evidence of small airway disease by forced expiratory flow rates or frequency dependence of compliance. We conclude that there is a high incidence of small airway disease in patients with sarcoidosis. There also appears to be a synergism between sarcoidosis and smoking that leads to a significant degree of hyperinflation of the lung.
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