Effect of Trimethoprim on the Occurrence of Drug-Resistant Coliform Bacteria in the Faecal Flora
作者:
Auli Toivanen,
Antero Kasanen,
Hannu Sundquist,
Paavo Toivanen,
期刊:
Chemotherapy
(Karger Available online 1976)
卷期:
Volume 22,
issue 2
页码: 97-103
ISSN:0009-3157
年代: 1976
DOI:10.1159/000221918
出版商: S. Karger AG
关键词: Trimethoprim;Sulphamethoxazole-trimethoprim;Coliform bacteria;Drug resistance
数据来源: Karger
摘要:
The occurrence of drug-resistant coliform bacteria was studied in the faecal flora of 30 persons receiving for 3 weeks either trimethoprim alone, a combination of sulphamethoxazole and trimethoprim, or a combination of sulphamethox-ydiazine and sulphamethoxazole. Bacterial sensitivity was tested against trimethoprim, sulphamethoxazole-trimethoprim, sulphamethoxazole, and sulphaisodimidine. After treatment with trimethoprim alone, no increase in the occurrence of strains resistant to either trimethoprim or sulphonamides was observed. After treatment with sulphamethoxazole-trimethoprim, the faecal flora contained an increased percentage of sulphonamide-resistant coliforms but significantly less than found after treatment with sulphamethoxydiazine-sulphamethoxazole. In the persons receiving the sulphonamides only, a rapid increase in sulphonamide-resistant coliforms was observed. During the whole study, only one trimethoprim-resistant coliform strain was detected.
点击下载:
PDF
(1715KB)
返 回