The Corticotropin-Releasing Factor Release in Rat Hypophysial Portal Blood Is Mediated by Brain Catecholamines
作者:
Viviane Guillaume,
Bernard Conte-Devolx,
Alain Szafarczyk,
Francis Malaval,
Nicole Pares-Herbute,
Michel Grino,
Gerard Alonso,
Ivan Assenmacher,
Charles Oliver,
期刊:
Neuroendocrinology
(Karger Available online 1987)
卷期:
Volume 46,
issue 2
页码: 143-146
ISSN:0028-3835
年代: 1987
DOI:10.1159/000124811
出版商: S. Karger AG
关键词: Catecholamines;Corticotropin-releasing factor;6-Hydroxydopamine;Hypothalamus;Hypophysial portal blood
数据来源: Karger
摘要:
In order to study the involvement of the hypothalamic corticotropin-releasing factor (CRF) in catecholamine-induced adrenocorticotropin (ACTH) secretion, we have measured CRF levels in rat hypophysial portal blood (HPB) after the pharmacological destruction of the ventral noradrenergic bundle (VNAB), using 6-hydroxydopamine (6-OHDA) stereotaxically injected into the VNAB. CRF levels in HPB were measured by radioimmunoassay, and the effects of 6-OHDA injection were controlled by the determination of catecholamine concentrations in the total hypothalamus. VNAB lesions induced a dramatic decrease in norepinephrine and epinephrine hypothalamic concentration. The CRF levels in HPB were also significantly reduced. These results suggest that central catecholamines exert a direct stimulatory control on the CRF release and play a major role in stress-induced ACTH secretion.
点击下载:
PDF
(897KB)
返 回