Ultrastructural Surface Alterations ofSerratia marcescensafter Exposure to Polymyxin B and/or Fresh Human Serum
作者:
Walter H. Traub,
Georg Acker,
Ingrid Kleber,
期刊:
Chemotherapy
(Karger Available online 1976)
卷期:
Volume 22,
issue 2
页码: 104-113
ISSN:0009-3157
年代: 1976
DOI:10.1159/000221919
出版商: S. Karger AG
关键词: Bactericidal activity (serum);Lipopolysaccharide;Polymyxin;Serratia marcescens
数据来源: Karger
摘要:
Exposure of Serratia marcescens cells to 10, 5, and 2.5 μg/ml of polymyxin B resulted in outer cell surface alterations that consisted of coarse, pleomorphic projections which revealed a double-contoured membrane structure. In contrast, fresh, but not heat-inactivated human serum caused the deposition of very fine, thread-like aggregates on the outer cell surface of exposed cells. The combination of polymyxin B and fresh human serum caused clearly discernible ultrastructural changes of the polymyxin and the fresh serum type, respectively
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