An extended bottleneck model: Accounting for the metabolic turnover effect in microorganisms
作者:
Pramod Agrawal,
H. C. Lim,
D. Ramkrishna,
期刊:
Journal of Chemical Technology and Biotechnology. Biotechnology
(WILEY Available online 1983)
卷期:
Volume 33,
issue 3
页码: 155-163
ISSN:0264-3421
年代: 1983
DOI:10.1002/jctb.280330305
出版商: John Wiley&Sons, Ltd.
关键词: Bottleneck model;proteins;metabolic turnover;transient growth;growth rate hysteresis
数据来源: WILEY
摘要:
AbstractThe bottleneck model proposed by Powell1can describe the growth rate hysteresis effect, but fails to account for the stationary state of microbial cultures. It is modified to obtain an extended bottleneck model (EBM), which adequately represents the stationary state of microbial cultures. The basis for modification is the metabolic turnover of proteins in microorganisms. Under special conditions the EBM can be reduced to the Powell bottleneck model or the Monod model. The EBM yields improved predictions of the transient growth ofE. coliin nitrogen limited cultures.
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