Alcohol modulation of single GABAAreceptor‐channel kinetics
作者:
Hideharu Tatebayashi,
Haruhiko Motomura,
Toshio Narahashi,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 8
页码: 1769-1775
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Alcohol;Channel kinetics;Ethanol;GABAAreceptor;Single GABA receptor channel
数据来源: OVID
摘要:
ALCOHOL modulation of single-channel kinetics of GABAAreceptor currents was studied with rat dorsal root ganglion neurons using the excised outside-out patch clamp technique. GABA (1 μM) alone or GABA (1 μM) plus ethanol (30–300 mM) or n-Octanol (30–300 μM) were applied by pressure ejection to evoke single-channel currents. The main single-channel conductance was not changed by either ethanol or n-Octanol at 25 pS. Both alcohols exerted the same effects on the single-channel kinetics, although n-Octanol was more potent than ethanol. The frequency of openings, the mean open time, the percentage of open time, the frequency of bursts, and the mean burst duration were all increased, but the mean closed time was decreased. These changes in channel kinetics account for the increase in whole-cell current amplitude caused by ethanol and n-Octanol.
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