Functional Activity of Class‐Specific Antibodies to Type III, Group B Streptococcus
作者:
JUDITH CAMPBELL,
CAROL BAKER,
TERESA METZGER,
MORVEN EDWARDS,
期刊:
Pediatric Research
(OVID Available online 1988)
卷期:
Volume 23,
issue 1
页码: 31-34
ISSN:0031-3998
年代: 1988
出版商: OVID
数据来源: OVID
摘要:
The functional activity of naturally acquired IgG and IgM with specificity for the capsular polysaccharide of type III, group B Streptococcus (III-GBS) was compared. Sera collected during convalescence from 14 infants who had developed specific antibodies following III-GBS infection were employed for separation of IgG from IgM by ion-exchange chromatography. Bactericidal killing of III-GBS was similar for IgG- and IgM-rich samples (37 and 42%, respectively) in reactions containing a mean of 1.0 or 1.9 μg/ml of III-GBS specific IgG or IgM antibody. Purified IgA lacked opsonophagocytic activity for III-GBS. These results indicate that III-GBS-specific IgG and IgM antibodies in infant sera promote opsonophagocytosis at low concentrations, and that their functional capacity is comparable.
点击下载:
PDF
(377KB)
返 回