ANTITUBERCULOUS ISONICOTINYLHYDRAZONES OF LOW TOXICITY
作者:
A. Zubrys,
C. O. Siebenmann,
期刊:
Canadian Journal of Chemistry
(NRC Available online 1955)
卷期:
Volume 33,
issue 1
页码: 11-14
ISSN:0008-4042
年代: 1955
DOI:10.1139/v55-003
出版商: NRC Research Press
数据来源: NRC
摘要:
In a search for antituberculous compounds of low toxicity, the isonicotinylhydrazones of monohydroxybenzaldehydes and of the corresponding aldehydophenoxyacetic acids were prepared. When testedinνiνo, the isonicotinylhydrazones of 2-formyl-phenoxyacetic acid and of 6-methoxy-2-formyl-phenoxyacetic acid showed the most marked antituberculous activity combined with low toxicity. The preparation of 6-methoxy-2-formyl-phenoxyacetic acid and of the isonicotinylhydrazone of 2-formyl-phenoxyacetic acid are described as representative examples. The results of microanalysis include data which define the antituberculous isonicotinylhydrazones of 2-hydroxybenzaldehyde, 4-hydroxybenzaldehyde, and 2-hydroxy-3-methoxybenzaldehyde (o-vanillin).
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