In a comparative study the clinical efficacy of five different treatments of keratoconjunctivitis infectiosa ovis (KIO) were tested, namely an intramuscular injection of chloramphenicol base (dosage 15 mg/kg), spiramycin base (Suanovil®dosages 10 to 25 mg/kg), oxytetracycline (Engemycine®Forte, Terramycin®LA, dosages respectively 5 and 10 mg/kg), tiamulin (Dynamutulin®, dosage 10 mg/kg) and subcutaneous injection of procaine penicillin G, benzathine penicillin G, and dihydrostreptomycin in the lower eyelid.