Quantitative and qualitative abnormalities in HIV-1-specific T cells
作者:
Nobukazu Watanabe,
Mariko Tomizawa,
Ai Tachikawa-Kawana,
Mieko Goto,
Atsushi Ajisawa,
Tetsuya Nakamura,
Aikichi Iwamoto,
期刊:
AIDS
(OVID Available online 2001)
卷期:
Volume 15,
issue 6
页码: 711-715
ISSN:0269-9370
年代: 2001
出版商: OVID
关键词: HIV-1;cytomegalovirus;interferon γ;perforin;intracellular cytokine;flow cytometry
数据来源: OVID
摘要:
ObjectiveTo assess the characteristics of CD4 and CD8 T cells specific for HIV-1 and cytomegalovirus (CMV) antigens in untreated and treated HIV-1-infected patients.MethodsAntigen-specific T cell frequencies were determined by flow cytometric detection of antigen-induced intracellular cytokines.ResultsIn untreated patients, HIV-1-specific CD4 T cell counts in peripheral blood were less than one tenth of CMV-specific CD4 T cell counts, while the number of specific CD8 T cells was approximately the same for both HIV-1 and CMV. In patients treated with highly active antiretroviral therapy (HAART) for less than 1.5 years, HIV-1-specific CD4and CD8T cell counts were significantly lower than those in untreated patients. Perforin expression in HIV-1-specific CD8 T cells was significantly lower than that in CMV-specific CD8 T cells.ConclusionThese data indicate that HIV-1-specific T cells in HIV-1-infected patients have quantitative and qualitative abnormalities.
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