Determination of Floctafenine in Presence of its Degradation Product Floctafenic Acid by Direct and Synchronous Spectrofluorimetry
作者:
Horria A. Mohamed,
期刊:
Analytical Letters
(Taylor Available online 1999)
卷期:
Volume 32,
issue 13
页码: 2641-2652
ISSN:0003-2719
年代: 1999
DOI:10.1080/00032719908542994
出版商: Taylor & Francis Group
关键词: Spectrofluorimetry;Synchronous;Direct;Floctafenine;Floctafenic acid;Tablets;Plasma, Urine;Mixtures
数据来源: Taylor
摘要:
A simple, rapid and sensitive spectrofluorimetric method for the determination of floctafenine I (FL) in the presence of its degradation product floctafenic acid II (FLA) is developed. The method involves measuring the fluorescence intensity of FL in acetonitrile and in the presence of triethylamine (TEA) at an emission wavelength of 470 nm (excitation at 360 nm) by direct spectrofluorimetry and at an emission 465 nm (excitation 355 nm) by synchronous spectrofluorimetry. At these conditions FLA does not interfere. FLA is determined alone by measuring the fluorescence intensity of its solution in acetonitrile, without addition of TEA, at emission wavelength 460 nm (excitation 355 nm). The proposed method has been used for the assay of FL in tablets, plasma, urine and in mixtures with FLA. It gave highly accurate results for recovery of FL in the presence of its related acid.
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