Correlation between Tubulointerstitial Nephropathy and Glomerular Lesions Induced by Adriamycin
作者:
A. Güezmes,
F. Fernández,
F. Garijo,
F. Val-Bernal,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 62,
issue 2
页码: 198-202
ISSN:1660-8151
年代: 1992
DOI:10.1159/000187033
出版商: S. Karger AG
关键词: Adriamycin nephrotoxicity;Focal and segmental glomerulosclerosis;Tubulointerstitial nephropathy;Morphometry
数据来源: Karger
摘要:
This paper describes a morphometric study of the evolution of tubulointerstitial nephropathy in adriamycin-induced focal and segmental glomerulosclerosis in Wistar rats over 32 weeks old. The earliest changes were located in the glomeruli. In the 10 week of the study, tubulointerstitial nephropathy appeared and, although the interstitial space increased after the 2nd week, this increase only became statistically significant after the 10 week. Proteinuria showed the highest correlation with the interstitial space, however, the interstitial space showed the highest correlation indices with the total number of glomeruli affected and to a lesser extent with adhesions to and thickening of Bowman’s capsul
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