The oxidation of methyl acetate (MA) has been investigated for the first time in a jet-stirred reactor at high temperature (∼ 800–1230K) and 10atm. Molecular species concentration profiles of O2H2, CO, CO2CH2O, CH4, C2H2, C2H4, C2H6and MA were obtained by probe sampling and GC analysis. MA oxidation in these conditions was modeled using a detailed kinetic reaction mechanism(66 species and 416 reactions, most of them reversible}. The proposed mechanism, also validated for the oxidation of CH4, C2H2, C2H4, C2H6, C3H6, acetaldehyde, ethylene oxide, and natural gas blends in the same conditions, is able to predict experimental results obtained in our high-pressure jet stirred reactor. Sensitivity analyses and reaction path analyses are used to interpret the present results.