Sideroblast Score: A Sensitive Indicator of Iron Deficiency and Hypoproliferative Anemia
作者:
Regula Baumgartner-Stäubli,
Eugen A. Beck,
期刊:
Acta Haematologica
(Karger Available online 1977)
卷期:
Volume 57,
issue 1
页码: 24-31
ISSN:0001-5792
年代: 1977
DOI:10.1159/000207856
出版商: S. Karger AG
关键词: Anemia;Bone marrow iron;Iron metabolism;Iron Staining;Sideroblasts
数据来源: Karger
摘要:
The detection and enumeration of sideroblasts depend critically on the method used for iron staining of bone marrow smears. Several methods proposed for semiquantitative evaluation of bone marrow hemosiderin (iron stores) were compared with respect to their suitability for detection of normal and abnormal sideroblasts. Instead of the customary percentage of sideroblasts, the introduction of a sideroblast score is proposed and its diagnostic relevance was prospectively studied. Low sideroblast scores are associated with iron deficiency and hypoproliferative anemia. A normal sideroblast score, despite the absence of stainable hemosiderin, excludes the diagnosis of severe iron depletion. Elevated sideroblast scores may be correlated either with iron overload and/or sideroblastic (sideroachrestic) anemias.
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