Vitamin a is stored as fatty acyl esters of retinol in the lacrimal gland
作者:
UbelsJohn L.,
OsgoodThomas B.,
FoleyKevin M.,
期刊:
Current Eye Research
(Taylor Available online 1988)
卷期:
Volume 7,
issue 10
页码: 1009-1016
ISSN:0271-3683
年代: 1988
DOI:10.3109/02713688809015147
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Many tissues which require vitamin A store the vitamin as long-chain fatty acyl esters of retinol. As part of a study designed to characterize vitamin A metabolism in the lacrimal gland, which transports retinol from blood to lacrimal gland fluid, extracts from lacrimal glands of rabbits and rats were analyzed by non-aqueous high performance liquid chromatography. Retinyl linoleate, retinyl palmitate, and retinyl stearate were identified in these extracts by their co-elution with standards, their retention time relative to retinyl palmitate, and their susceptibility to hydrolysis by saponification. Retinyl palmitate was present in rabbit lacrimal gland at 51.0↣10.1 ng/g tissue. After treatment of vitamin A-deficient rabbits with orally administered [11, 12-3H] retinyl acetate, the radiolabeled esters retinyl linoleate, palmitate, and stearate were extracted from the lacrimal glands. These data show that the lacrimal gland stores vitamin A as fatty acyl esters of retinol.
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