A review of the animal pharmacology of clobazam: An update
作者:
Stuart Fielding,
Harbans Lal,
期刊:
Drug Development Research
(WILEY Available online 1982)
卷期:
Volume 2,
issue S1
页码: 17-21
ISSN:0272-4391
年代: 1982
DOI:10.1002/ddr.430010705
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: anxiolytic;anticonvulsant;drug discrimination;myoclonic seizure
数据来源: WILEY
摘要:
AbstractClobazam is a 1, 5‐benzodiazepine with significant activity in preclinical tests predictive of potential clinical antianxiety activity. Clinical efficacy equivalent to diazepam has been established with minimal effects on psychomotor performance. Clobazam has also been found to have a broad spectrum of anticonvulsant activity with acceptable toxicity and to be active in suppressing aggressive behavior in rodents. This compound appears to have less of an effect on motor coordination, muscle tone, behavioral depression and hyporeflexia than standard reference compounds in various species as well as little or no apparent effect on memory and learning in animals and humans. The major metabolite, desmethylclobazam, is also an anxiolytic candidate approximately 10 times less potent than diazepam and a potent anticonvulsant with a complete lack of sedation. These compounds represent a new classification of pharmaceutical agents in which antianxiety and anticonvulsant effects can be achieved without sedative or depressive side effect
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