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Evidence and Quantification of the Vasopressin Arterial Pressure Control System in the Dog

 

作者: ALLEN COWLEY,   SARA SWITZER,   MEREDITH GUINN,  

 

期刊: Circulation Research  (OVID Available online 1980)
卷期: Volume 46, issue 1  

页码: 58-67

 

ISSN:0009-7330

 

年代: 1980

 

出版商: OVID

 

数据来源: OVID

 

摘要:

We determined quantitatively the importance of vasopressin (AVP) release in the regulation of arterial pressure during hemorrhagic hypotension in dogs. The recovery of arterial pressure after rapid hemorrhage was studied in 10 dogs with spinal cord destruction below the level of C-l to remove efferent sympathetic nerve activity. Bilateral nephrectomy was used to remove the reninangiotensin system. Results for this group were compared to those for another group of dogs in which the entire central nervous system, including the pituitary gland, were removed surgically. In all groups, arterial pressure was lowered rapidly from an average control value of 106 ± 2 (mean ± SE) to 51 ± 1 mm Hg by hemorrhage. In dogs with spinal cord destruction and bilateral nephrectomy, arterial pressure rose from 51 mm Hg to 89 ± 3 mm Hg in 3 minutes and stabilized at that level over the next 30 minutes, representing a 71% compensation of arterial pressure. Left atrial pressure fell from 3.3 to 0.8 mm Hg during hemorrhage and subsequently rose only 12% during the hemorrhage. Plasma AVP rose during hemorrhage from 19 ± 2 to 75 ± 10 μU/ml. Injection of the competitive AVP inhibitors, [1-deaminopenicillamine, 4-valine]-8-D-arginine-vasopressin (dPVDAVP), completely reversed the effects and returned the compensated pressure to 50 mm Hg. In the complete absence of the central nervous system, arterial pressure compensation averaged only 10 ± 3%. Plasma osmolality, sodium and potassium concentrations, hematocrit, and heart rate were unchanged in all experimental groups. The relationships involved in the AVP-arterial pressure control system were determined quantitatively and analyzed. A systems analysis using experimentally determined values for AVP secretion and metabolism, plasma AVP, and changes in arterial pressure closely predicted the changes observed during hemorrhage. It appears from this study that AVP has potent systemic vasoconstrictor actions enabling it to make a significant contribution in the restoration of arterial pressure during hemorrhage. Circ Res 46: 58-67, 1980

 

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