Spontaneous and antibody‐dependent cellular immune reactions to ethanol‐altered hepatoma cells
作者:
T. Poralla,
T. H. Hütteroth,
A. Knuth,
M. Staritz,
H. P. Dienes,
K.‐H. Meyer Büschenfelde,
期刊:
Liver
(WILEY Available online 1987)
卷期:
Volume 7,
issue 1
页码: 50-57
ISSN:0106-9543
年代: 1987
DOI:10.1111/j.1600-0676.1987.tb00315.x
出版商: Blackwell Publishing Ltd
关键词: alcoholic liver disease;cellular cytotoxicity;hepatoma cells
数据来源: WILEY
摘要:
ABSTRACT—Spontaneous cell‐mediated cytotoxicity (SCMC), antibody‐dependent cellular cytotoxicity (ADCC) and proliferative lymphocyte stimulation in alcoholic liver disease (ALD) were investigated. Peripheral blood lymphocytes (PBL) from eight patients with advanced ALD and nine normal controls were tested against hepatoma cells (PLC/PRF/5) as targets. Target cells were grown in either normal culture medium or medium supplemented with 1 and 5% ethanol, respectively, for 24 to 48 h. Ethanol‐exposed hepatoma cells exhibited profound and characteristic morphological alterations. Ethanol preincubation, however, proved to be without effect on immune reactions. Provided that hepatoma cells are an appropriate model, we assume that the proposed immune reactions in ALD are based on metabolic interactions operative onlyin vivobut do not parallel morphological alterations of liver cells directly induced by
点击下载:
PDF
(2229KB)
返 回