CYTOGENETIC OBSERVATIONS FOLLOWING THALLIUM POISONING
作者:
Philippe Hantson Ria Desoir Eliane D. Leonard, Paul Mahieu,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1997)
卷期:
Volume 50,
issue 2
页码: 97-100
ISSN:0098-4108
年代: 1997
DOI:10.1080/009841097160500
出版商: Informa UK Ltd
数据来源: Taylor
摘要:
Observations have been performed on peripheral blood lymphocytes from a patient having ingested 200 mg thallium sulfate, in order to evaluate the ability of the compound to produce cytogenetic damage in vivo in humans. Our results demonstrate that neither the yield of structural chromosome aberrations nor sister chromatid exchanges were significantly modified. The drastic increase of binucleated cells with micronuclei indicates that thallium sulfate has in common with many metallic compounds the ability to interfere with chromosome distribution.
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