Recovery of cholinesterase activity in mallard ducklings administered organophosphorus pesticides
作者:
W. James Fleming,
StevenP. Bradbury,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1981)
卷期:
Volume 8,
issue 5-6
页码: 885-897
ISSN:0098-4108
年代: 1981
DOI:10.1080/15287398109530123
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Oral doses of the organophosphorus pesticides acephate, dicrotophos, fensuifothion, fonofos, malathion, and parathion were administered to mallard ducklings (Anas platyrhynchos), and brain and plasma cholinesterase (ChE) activities were determined for up to 17 d after dosing. In vivo recovery of brain ChE activity to within 2 standard deviations of the mean activity of undosed birds occurred within 8 d, after being depressed an average of 25–58% at 24 h after dosing. In vivo recovery of plasma ChE appeared as fast as or faster than that of brain, but the pattern of recovery was more erratic and therefore statistical comparison with brain ChE recovery was not attempted. In vitro tests indicated that the potential for dephosphorylation to contribute to in vivo recovery of inhibited brain ChE differed among chemical treatments.
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