Dopaminergic and Cholinergic Influences on the Growth Hormone Response to Growth Hormone-Releasing Hormone in Man
作者:
Giuseppe Delitala,
Mario Palermo,
Richard Ross,
David Coy,
Michael Besser,
Ashley Grossman,
期刊:
Neuroendocrinology
(Karger Available online 1987)
卷期:
Volume 45,
issue 3
页码: 243-247
ISSN:0028-3835
年代: 1987
DOI:10.1159/000124732
出版商: S. Karger AG
关键词: Dopamine;Acetylcholine;Bromocriptine;Domperidone;Pirenzepine;GHRH(1-29)NH2;Growth hormone
数据来源: Karger
摘要:
It is well established that compounds that modify dopaminergic and cholinergic activity in man may induce changes in circulating growth hormone (GH). We have, therefore, investigated the effect of a dopamine agonist, bromocriptine, and a dopamine antagonist, domperidone, as well as a muscarinic cholinergic antagonist, pirenzepine, on the GH response to an analogue of GH-releasing hormone (GHRH) in normal male subjects. GHRH(1–29)NH2 induced a rise in serum GH that was augmented by bromocriptine, antagonized by pirenzepine, but was unaltered by domperidone. As this dose of GHRH(l-29) NH2 has been shown to be maximally stimulatory to GH release, it is suggested that there are dopamine stimulatory and cholinergic inhibitory receptors to GH release independent of GHRH in ma
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