Drug Bioavailability Studies
作者:
WagnerJohn G.,
期刊:
Hospital Practice
(Taylor Available online 1977)
卷期:
Volume 12,
issue 1
页码: 119-127
ISSN:2154-8331
年代: 1977
DOI:10.1080/21548331.1977.11707065
出版商: Taylor&Francis
数据来源: Taylor
摘要:
All drugs are not created equal even if the pharmacopoeia seems to suggest they are. Factors that affect bioavailability among drugs of the same type (especially oral drugs) include not only disintegration and absorption rates but also the amount of food taken before or with the dose, interactions with other drugs, the physical state of the patient, and the“first-pass effect”upon drugs with high liver clearance.
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