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An HPLC fluorescence detection system for amines

 

作者: R. W. Frei,   J. F. Lawrence,   U. A. Th. Brinkman,   I. Honigberg,  

 

期刊: Journal of High Resolution Chromatography  （WILEY Available online 1979）
卷期: Volume 2, issue 1  

页码: 11-14

 

ISSN:0935-6304

 

年代: 1979

 

DOI:10.1002/jhrc.1240020106

 

出版商: Wiley Subscription Services, Inc., A Wiley Company

 

关键词: Liquid chromatography;Fluorescence;Ion‐pair extraction;Amines;Post‐column reaction;Auto‐analyser

 

数据来源: WILEY

 

摘要:

AbstractA detection system is described which is based on fluorescent ion‐pair formation between tertiary amine drugs and dimethoxyanthracene sulphonate. A dynamic micro‐extraction principle is then used to isolate the ion‐pairs from the excess reagent. The band broadening of this extraction detector was kept below 20% using standard auto‐analyser equipment. With the enhanced selectivity and sensitivity of this approach it was possible to analyse chloropheniramine in urine at ppb concentrations using a pre‐column clean‐up trace enri

 

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