The Role of Endothelial Cells and Subendothelial Components in the Initiation of Blood Coagulation
作者:
B. Østerud,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1979)
卷期:
Volume 8,
issue 3-5
页码: 324-331
ISSN:1424-8832
年代: 1979
DOI:10.1159/000214322
出版商: S. Karger AG
关键词: Collagen;Lysed endothelial cells;Procoagulant activity;Anti-tissue factor;125I-factor IX
数据来源: Karger
摘要:
The effect of collagen on isolated platelets, platelet-rich plasma and whole blood has been studied. Collagen failed to generate factor XIa-like activity in mixtures of isolated platelets, collagen and Ca++. Moreover, collagen added to whole blood or platelet-rich plasma containing 125I-factor IX and Ca++, also failed to form cleaved (activated) factor IX. In preliminary studies, lysed endothelial cells were found to enhance the formation of factor Xa and thrombin and to induce cleavage of 125I-factor IX in normal plasma, factor XII and factor-XI-deficient plasma even in the presence of antibody to tissue factor.
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