Using sets of synthetic, sparse acoustic stimuli (SAS) we have examined two patients who underwent unilateral surgical excision of all auditory cortex. Patient 1, an 8‐year‐old girl, had right hemispherectomy at age 5 years. Patient 2, a 30‐year‐old woman, had suffered extensive left hemisphere damage at birth and had left hemispherectomy at age 29 years; preoperative carotid amytal studies showed right hemisphere dominance for speech. Patients classified sets of SAS presented monaurally; responses were arranged in multidimensional contingency tables and analyzed for departure from homogeneity. For sets with falling F2(|γε|‐|yε|). each patient classified appropriately SAS presented to ear opposite remaining hemisphere (p= 0.0001); however, each classified randomly SAS presented to ear opposite excision (p= 0.9997). Repeated testing demonstrated no learning effects. These findings permit following conclusions for these SAS: (1) Neither subcortical mechanisms nor ipsilateral input to remaining auditory cortex are sufficient to classify these SAS appropriately. (2) If “plasticity” operated in patient 2, it was not evident in altered auditory connectivity.