Ataxia Telangiectasia with Persistent Epstein‐Barr Virus Infection and Malignant Lymphome
作者:
Yukio Sakiyama,
Y. Takahashi,
H. Tsuneta,
S. Matsumoto,
期刊:
Pediatrics International
(WILEY Available online 1984)
卷期:
Volume 26,
issue 1
页码: 51-55
ISSN:1328-8067
年代: 1984
DOI:10.1111/j.1442-200X.1984.tb00598.x
出版商: Blackwell Publishing Ltd
关键词: Ataxia telangiectasis;persistent EBV infection;B‐cell lymphoma
数据来源: WILEY
摘要:
AbstractAtaxia telangiectasia is agenetically determined immunodeficiency with predisposition to malignancy. Herein we report a case of ataxia telangiectasis in a child who had showed high antibody titers to viral capsid antigen (VCA), presence of antibodies to Epstein‐Barr virus (EBV) induced early antigen (EA), low titers of antibodies to EBV associated nuclear antigen (EBNA), and a high incidence of EBNA‐positive cells in the peripheral blood without symptoms of infectious mononucleosis before succumbing to malignant lymphoma five years later. We hypothesize the association betwen some cytogenetic defects and persistent EBV infection on the development of the malignant lymphoma in this pati
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