High-Dose Hemithorax Irradiation in a Patient With Recurrent ThymomaA Study of Pulmonary and Cardiac Radiation Tolerance
作者:
Jeffrey Bogart,
Robert Sagerman,
期刊:
American Journal of Clinical Oncology: Cancer Clinical Trials
(OVID Available online 1999)
卷期:
Volume 22,
issue 5
页码: 441-441
ISSN:0277-3732
年代: 1999
出版商: OVID
关键词: Hemithorax irradiation;Thymoma;Pulmonary function.
数据来源: OVID
摘要:
Malignancy spread throughout a hemithorax without distant metastasis poses a difficult therapeutic challenge. Irradiation is often not considered because of the risk of pulmonary and cardiac toxicity. We report on a patient with thymoma recurrent throughout the left pleural cavity. Disease progressed despite chemotherapy, and subsequently a radical course of radiotherapy (6,600 cGy) was delivered to the entire hemithorax. Tumor regressed markedly by the completion of radiotherapy. Although tumor regrowth was noted 1 year after radiotherapy, the patient remained markedly improved symptomatically until shortly before her death 2 years after radiotherapy. Pulmonary function tests at 1 year (forced expiratory volume of the first second and forced vital capacity) were similar to pretreatment values, and cardiac function at 2 years remained essentially normal. High-dose hemithorax irradiation may be a consideration in select cases.
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