The Hemidesmosome: A Target in Auto-Immune Bullous Disease
作者:
R.A.J. Eady,
期刊:
Dermatology
(Karger Available online 1994)
卷期:
Volume 189,
issue 1
页码: 38-41
ISSN:1018-8665
年代: 1994
DOI:10.1159/000246926
出版商: S. Karger AG
关键词: Hemidesmosome;Basement membrane;Bullous pemphigoid antigen;Anchoring filament;α6β4-Integrin
数据来源: Karger
摘要:
Hemidesmosomes are subcellular structures that are involved in the attachment of a variety of epithelial cells, including basal epidermal keratinocytes, to the extracellular matrix. Like desmosomes, they provide a link between the intracytoplasmic keratin intermediate filaments and the plasma membrane. Major hemidesmosome plaque components include the bullous pemphigoid antigens of 230 and 180 kD and the α6β4-integrin. These transmembrane proteins may associate extracellularly with anchoring filament components including the 19-DEJ-1 proteoglycan and the polymeric proteins nicein/kalinin and epiligrin. Several of these hemidesmosome-related components have been implicated as targets for circulating auto-antibodies in immunobullous disorder
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