Regional Node Failure in Patients With Four or More Positive Lymph Nodes Submitted to Conservative Surgery Followed by Radiotherapy to the Breast
作者:
Cynthia Aristei,
Anna Marsella,
Fausto Chionne,
Bianca Panizza,
Luigi Marafioti,
Anna Mosconi,
Roberta Cherubini,
Mariantonietta Colozza,
期刊:
American Journal of Clinical Oncology: Cancer Clinical Trials
(OVID Available online 2000)
卷期:
Volume 23,
issue 3
页码: 217-221
ISSN:0277-3732
年代: 2000
出版商: OVID
关键词: Breast cancer;Conservative surgery;Radiotherapy;Regional nodal recurrence.
数据来源: OVID
摘要:
A retrospective analysis was conducted to evaluate the incidence of nodal failure in a subgroup of patients who had T1-T2 breast cancer and four or more positive nodes. Sixty-four 5 patients ranging in age from 29 to 73 years (median, 51) received conservative surgery followed by radiotherapy to the breast between November 1980 and May 1995. Adjuvant chemotherapy was administered to 56 patients, 27 of whom were also treated with tamoxifen, which was used alone in 5 patients. Three patients received no adjuvant treatment. Sixty-two patients are evaluable for regional node failure. There were 10 nodal failures, 4 in the axillary and 6 in the supraclavicular regions, in 9 patients, at a median of 56.5 and 27 months, respectively. There was no internal mammary node failure. Median follow-up was 72.6 months. The 10-year probability of developing axillary and supraclavicular failure is 13.9 ± 7.7% and 10.5 ± 4.1%, respectively. Prognosis was better for patients with axillary and breast recurrence and worse when relapse was in the supraclavicular region. On the basis of our results and data already published in premenopausal patients, we believe that radiotherapy to the supraclavicular region should be considered in patients with four or more positive axillary nodes, after a complete dissection.
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