Comparison of variousN-methyl-D-aspartate receptor antagonists in a model of short-term memory and on overt behaviour
作者:
K M Doyle,
S Feerick,
D L Kirkby,
A Eddleston,
G A Higgins,
期刊:
Behavioural Pharmacology
(OVID Available online 1998)
卷期:
Volume 9,
issue 8
页码: 671-681
ISSN:0955-8810
年代: 1998
出版商: OVID
关键词: CPP;delayed match to position;dizocilpine;(+)-HA-966;rat;ifenprodil;learning;memory;N-methyl-D-aspartate receptor
数据来源: OVID
摘要:
This study examined the effects on rat behaviour of antagonists acting at various sites on the N-methyl-D-aspartate (NMDA) receptor complex, i.e. the glutamate recognition site (CPP), ion channel (dizocilpine), glycine recognition site [(+)-HA-966] and the NR2B subunit-selective compound ifenprodil. Specifically, the effects of these agents were examined on working memory, assessed using the operant delayed match-to-position task (DMTP), and overt behaviour, assessed (a) in animals responding for food under a variable interval 20-s (VI20) schedule and (b) by spontaneous behaviour. Dizocilpine, CPP and (+)-HA-966 each reduced accuracy in the DMTP task independent of delay. At equivalent doses, changes in locomotor behaviour and VI20 responding were evident. In contrast, ifenprodil failed to impair accuracy in the DMTP task, even at doses that affected other performance measures and reduced VI20 responding. The relevance of these observations to neuroprotective and anticonvulsant doses of these compounds is considered.
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