Industrial injuries are often open wounds contaminated with grease. Commercial compounds used for removing grease from, intact skin are composed of petroleum distillates. These products are occasionally used to remove grease from open wounds. Using an animal model, this study examines the use of commercial compounds in open wounds in comparison with mild detergent and water. A clear correlation is established between their use and adverse tissue reaction. The use of soap and water as opposed to petroleum-based compounds is recommended for removal of grease from a wound.