首页   按字顺浏览 期刊浏览 卷期浏览 In situ hybridization and translocation breakpoint mapping
In situ hybridization and translocation breakpoint mapping

 

作者: B.S. Emanuel,   J.R. Selden,   E. Wang,   P.C. Nowell,   C.M. Croce,  

 

期刊: Cytogenetic and Genome Research  （Karger Available online 1984）
卷期: Volume 38, issue 2  

页码: 127-131

 

ISSN:1424-8581

 

年代: 1984

 

DOI:10.1159/000132044

 

出版商: S. Karger AG

 

数据来源: Karger

 

摘要:

In situ chromosomal hybridization of a probe for part of the lamda light chain constant region (Cλ) has demonstrated that the 22q11 breakpoints of chronic myelogenous leukemia (CML) t(9;22) and Burkitt lymphoma t(8;22) are not identical. For CML, the breakpoint is distal to the IGLC genes, whereas for Burkitt lymphoma it is proximal. The study provides direct evidence for regional assignment of the IGLC gene cluster to 22q11

 

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