Catabolite-controlled regulation of glutamate dehydrogenases ofNeurospora crassa
作者:
M. Kapoor,
A. K. Grover,
期刊:
Canadian Journal of Microbiology
(NRC Available online 1970)
卷期:
Volume 16,
issue 1
页码: 33-40
ISSN:0008-4166
年代: 1970
DOI:10.1139/m70-006
出版商: NRC Research Press
数据来源: NRC
摘要:
The effect of the presence of catabolites in the growth medium on the synthesis of the two glutamate dehydrogenases ofNeurospora crassais reported. It has been demonstrated that the nicotinamide adenine dinucleotide (NAD) specific glutamate dehydrogenase is subject to repression by sucrose and glucose. Nicotinamide adenine dinucleotide phosphate (NADP) specific glutamate dehydrogenase, on the other hand, is induced by increasing concentrations of the catabolite. These data suggest that a reciprocal relationship exists between these two enzymes during synthesis in the presence of catabolites. Growth in higher concentrations of sucrose led to the formation of two isoenzymes of the NADP-specific enzyme; the second or the minor isozyme is not produced at very low catabolite concentrations. The catabolite effects produced by sucrose are overcome by glutamate, if the latter is incorporated into the growth medium. Glutamate represses both the isozymes of NADP-specific enzyme.
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