Role of the Kidney in the Production of a Low Molecular Weight Growth Factor (MW<1000 Da): Experimental Study in the Pig
作者:
JacobC.,
HubertJ.,
MaachiF.,
PungaA.,
DoussetB.,
JunkeE.,
BellevilleF.,
期刊:
Renal Failure
(Taylor Available online 1995)
卷期:
Volume 17,
issue 4
页码: 339-347
ISSN:0886-022X
年代: 1995
DOI:10.3109/08860229509037600
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Small peptide molecules known as low molecular weight growth factor (LMW-GF) have been identified in human serum. They enhance the effect of IGF-1 (insulin-like growth factor) on proteoglycan synthesis. In the present work we investigated the role played by the kidney in the production of LMW-GF, using the pig as an experimental model. Six pigs underwent bilateral nephrectomy followed 24 h later by orthotopic autotransplantation of the kidney. Renal and liver functions were evaluated by measurement of serum creatinine, urea, electrolytes, amino transferases (ASAT, ALAT), proteins, and bilirubin. LMW-GF was measured by bioassay using 11-day-old pelvic chick embryo cartilages. We observed that LMW-GF quickly disappeared from pig serum after nephrectomy and only reappeared when transplantation was successful. Reappearance of LMW-GF can precede improvement of renal function evaluated by plasma creatinine levels. These data appear to demonstrate that the kidney is involved in LMW-GF production.
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