Increase of DNA Synthesis in Uterine Adenomyosis in Mice with Ectopic Pituitary Isograft
作者:
S. Sakamoto,
T. Mori,
T. Singtripop,
S. Kawashima,
S. Suzuki,
H. Kudo,
K. Sawaki,
H. Nagasawa,
期刊:
Cells Tissues Organs
(Karger Available online 1992)
卷期:
Volume 145,
issue 2
页码: 162-166
ISSN:1422-6405
年代: 1992
DOI:10.1159/000147359
出版商: S. Karger AG
关键词: Adenomyosis;Ectopic pituitary isograft;Thymidylate synthetase;Thymidine kinase;Immunocytochemistry;Bromodeoxyuridine
数据来源: Karger
摘要:
Ectopic pituitary isografts (EPI) have been found to induce a high incidence of uterine adenomyosis in SHN mice. All the SHN mice given EPI in the right uterus at 40 days of age developed uterine adenomyosis, and more than 80% of mice showed the genesis of subserosal nodules, an advanced state of adenomyosis, 65 days after EPI. Activities of both thymidylate synthetase and thymidi re kinase, i.e. DNA-synthesizing enzymes in de novo and salvage pathways of pyrimidine metabolism, respectively, were significantly increased in EPI-induced uterine adenomyosis to approximately 2-fold those in normal control uteri. Bromodeoxyuridine-immunoreactive cells were regarded as the cells in S phase, a id the number in the endometrial epithelium and stroma in EPI-induced uterine adenomyosis was more than 1.5-fold that in normal control uteri. EPI may affect the genesis of uterine adenomyosis generally, but not locally, because there were no differences between the right uterus with EPI and the left without EPI in the incidence of adenomyosis, histology or DNA-synthesizing enzyme activities.
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