首页   按字顺浏览 期刊浏览 卷期浏览 Pharmacodynamic Interactions Between Phenytoin and ValproateIndividual and Combined Ant...
Pharmacodynamic Interactions Between Phenytoin and ValproateIndividual and Combined Antiepileptic and Neurotoxic Actions in Mice

 

作者: M. Chez,   B. Bourgeois,   C. Pippenger,   W. Knowles,  

 

期刊: Clinical Neuropharmacology  (OVID Available online 1994)
卷期: Volume 17, issue 1  

页码: 32-37

 

ISSN:0362-5664

 

年代: 1994

 

出版商: OVID

 

关键词: Antiepileptic drugs;Valproate;Phenytoin;Drug interactions;Monotherapy.

 

数据来源: OVID

 

摘要:

Summary: Although the current trend is to use monotherapy in the treatment of epilepsy, combination therapy is still employed in patients who have failed to respond to monotherapy. There is little clinical or experimental documentation of evidence against or in favor of anticonvulsant combination therapy. In this context, anticonvulsant and neurotoxic pharmacodynamic interactions between phenytoin (PHT) and valproate (VPA) were assessed in an experimental model in mice. All results were expressed in terms of brain drug concentrations for eliminating any pharmacokinetic interaction from the analysis. Both the median neurotoxic and the median anticonvulsant brain concentrations were determined for each drug used alone and for the combination. The interaction for the combination of PHT and VPA was shown to be supraadditive for the anticonvulsant activity, indicating an antiepileptic potentiation, whereas neurotoxicity was simply additive. These results suggest a potential benefit in terms of overall efficacy versus toxicity for the combination of PHT and VPA, as compared with PHT or VPA used alone.

 

点击下载:  PDF (338KB)



返 回