Effect of Ticlopidine on Neutrophil Chemotaxis in Rats
作者:
Michael Cohn,
Yaacov Matzner,
Amiram Eldor,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1985)
卷期:
Volume 15,
issue 2
页码: 114-118
ISSN:1424-8832
年代: 1985
DOI:10.1159/000215131
出版商: S. Karger AG
关键词: Ticlopidine;Platelet aggregation;Chemotaxis;Neutrophil;Rat
数据来源: Karger
摘要:
The ex vivo effect of oral administration of ticlopidine on rat neutrophil chemotaxis was evaluated. Rats received either 3 oral doses (100 mg/kg body weight) of the drug, within a period of 48 h, via a gastric tube, or the drug was administered in drinking water for 14 days at a dosage of 75 mg/kg/day. Absorption of the drug was manifested by significant inhibition of adenosine diphosphate- (ADP-)induced platelet aggregation. No impairment of neutrophil chemotaxis toward zymosan-activated serum was observed in the ticlopidine-treated animals. These results indicate that concentrations of ticlopidine that significantly inhibit platelet function in rats are without effect on neutrophil chemotaxis toward zymosan-activated serum.
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