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Gastrointestinal Receptors and Drugs in Motility Disorders

 

作者: H.-J. Ruoff,   B. Fladung,   P. Demol,   T.R. Weihrauch,  

 

期刊: Digestion  (Karger Available online 1991)
卷期: Volume 48, issue 1  

页码: 1-17

 

ISSN:0012-2823

 

年代: 1991

 

DOI:10.1159/000200658

 

出版商: S. Karger AG

 

关键词: Prokinetics;Opioids;Ca2+channel blockers;Therapeutic efficacy;Motility disorders;Gastrointestinal receptors;Muscarinic drugs;Adrenergic drugs

 

数据来源: Karger

 

摘要:

The review describes gastrointestinal receptors which are of therapeutic interest for the treatment of motility disorders. It updates the present knowledge on muscarinic, adrenergic, dopamine, opioid and dihydropyridine receptors, their subtypes, cellular sites and functional role as drug targets. On the basis of this pharmacological receptor concept, drugs like bethanechol, clonidine, lidamidine, metoclopramide, domperidone, cisapride, loperamide and nifedipine are evaluated in proven and potential indications. In view of the very complex regulation of motility, our understanding of receptors is still fragmentary and our tools to treat motility disorders do not fulfil all therapeutic requirements. This review tries to point out the areas of particular need for further basic research and the prospects of further drug development.

 

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