Infusion of prepro-VIP Derived Peptides in Man: Effect on Secretion of Prolactin
作者:
Yiangos Yiangou,
Jaswinder S. Gill,
Bobbie J. Chrysanthou,
Jacky Burrin,
Stephen R. Bloom,
期刊:
Neuroendocrinology
(Karger Available online 1988)
卷期:
Volume 48,
issue 6
页码: 615-618
ISSN:0028-3835
年代: 1988
DOI:10.1159/000125071
出版商: S. Karger AG
关键词: Prolactin;Luteinizing hormone;Vasoactive intestinal peptide;Peptide histidine methionine;Peptide histidine valine
数据来源: Karger
摘要:
Infusion of the three human prepro-VIP derived peptides [vasoactive intestinal peptide (VIP), peptide histidine methionine (PHM) and the newly discovered peptide histidine valine (PHV-42)] at a constant nominal rate of 5 pmol/kg/min in 6 healthy volunteers for 60 min resulted in plateau plasma levels of 56,475 and 1,052 pmol/l, respectively. Although these values were above those found in the circulation under physiological conditions, only VIP caused a significant rise of prolactin (PRL) during, and postinfusion. Circulating luteinizing hormone and cortisol concentrations remained unchanged. As peptide histidine isoleucine, the porcine equivalent of PHM, has been postulated to be a potent hypophyseal portal pituitary PRL-releasing factor in the rat, we suggest that in man, VIP is more active than either PHM or PHV-42, and is likely to be a better candidate.
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