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Recombinant Human Erythropoietin Reduces Free Erythrocyte Protoporphyrin Levels in Patients on Chronic Dialysis

 

作者: Valter Piazza,   Giuseppe Villa,   Franco Galli,   Siro Segagni,   Giacomo Bovio,   Francesco Poggio,   Loredana Picardi,   Alessandro Salvadeo,  

 

期刊: Nephron  （Karger Available online 1992）
卷期: Volume 61, issue 1  

页码: 54-57

 

ISSN:1660-8151

 

年代: 1992

 

DOI:10.1159/000186834

 

出版商: S. Karger AG

 

关键词: Erythropoietin;Heme;Hemodialysis;Porphyrins

 

数据来源: Karger

 

摘要:

We studied the significance of free erythrocyte protoporphyrin (FEP) in relation to iron status, aluminum levels and anemia in uremic patients on chronic dialysis. All but 1 patient showed high FEP values closely related to the degree of anemia. Increased FEP levels are due to a defective heme synthesis, not related to iron deficiency or aluminum overload. Treatment of anemia with recombinant human erythropoietin reduced FEP values. We therefore hypothesize that recombinant human erythropoietin ameliorates an enzymatic defect in heme synthesis.

 

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