AbstractBecause it was one of Holland's first major attempts at examining the possible need to control a science and technology, the Dutch commission on genetic manipulation may influence the conduct of future enquiries. Thus its procedures merit careful assessment.Possible lessons concern the composition of expert panels if bias is to be allowed for; the treatment of lay members and of public perceptions and fears (be they right or wrong); the uncovering and priority given to ethical and religious views; paying attention to non-technical risks (eg terrorism); rights to call in outside witnesses; and more. A crucial part of the framework is whether the commission should be seeking to maximize good, or simply to minimize evil; the answer affects the relevance of analysis of possible benefits.