Taurine analogues as modifiers of the accumulation of45calcium ions in a rat retinal membrane preparation
作者:
LombardiniJohn B.,
LiebowitzStephen M.,
期刊:
Current Eye Research
(Taylor Available online 1990)
卷期:
Volume 9,
issue 12
页码: 1147-1156
ISSN:0271-3683
年代: 1990
DOI:10.3109/02713689009003471
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The effects of a series of taurine analogues on the accumulation of45calcium ions in a crude rat retinal membrane preparation are reported.45Calcium ion accumulation was measured at high (1.4 mM) calcium ion concentration in the presence and absence of ATP. In the absence of ATP, taurine andα-sulfo-β-ala-nine both inhibit45calcium ion accumulation.α-Sulfo-β-alanine is the more potent of the two compounds (50% vs. 30% inhibition at 20 mM). Thetransaminocycloalkanesulfonic acid analogues of taurine [(±)trans-2-aminocyclopen-tanesulfonic acid and (±)trans-2-aminocyclo-hexanesulfonic acid] are stimulators (3- to 4-fold) of45calcium ion accumulation. In the presence of ATP (1.2 mM), taurine and the analogues of taurine had no effect. Structure-activity-relationships of these compounds pertinent to their effects on45calcium ion accumulation at a high calcium ion concentration and in the absence of ATP are discussed. In addition, the inhibitory effects of taurine on45calcium accumulation in subfractions of the retina (rod outer segments, synaptosomes, and mitochondria) and the effects of the divalent ionophore A23187 on45calcium accumulation were also investigated.
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