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Chlorpromazine Disposition in Relation to Age in Children

 

作者: Mario Furlanut,   Pierpaola Benetello,   Massimo Baraldo,   Gabriella Zara,   Giuseppe Montanari,   Filiberto Donzelli,  

 

期刊: Clinical Pharmacokinetics  （ADIS Available online 1990）
卷期: Volume 18, issue 4  

页码: 329-331

 

ISSN:0312-5963

 

年代: 1990

 

出版商: ADIS

 

数据来源: ADIS

 

摘要:

The pharmacokinetics of chlorpromazine after intravenous infusion were studied in 25 children.The pharmacokinetic parameters studied are markedly different from those reported for adults. A clear relationship was demonstrated between age, serum terminal half-life (r = 0.75) and systemic clearance (r = −0.43). It appears that the pharmacokinetics of chlorpromazine are more rapid in children than in adults.

 

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