Cardiovascular effects of social stress in borderline hypertensive rats
作者:
A. Mick Gelsema,
Regien Schoemaker,
Marcel Ruzicka,
Nichola Copeland,
期刊:
Journal of Hypertension
(OVID Available online 1994)
卷期:
Volume 12,
issue 9
页码: 1019-1028
ISSN:0263-6352
年代: 1994
出版商: OVID
关键词: Psychosocial stress;dietary sodium;hypertension;cardiac hypertrophy;borderline hypertensive rat.
数据来源: OVID
摘要:
ObjectiveTo test the hypothesis that chronic exposure to psychosocial stress, alone or in combination with elevated levels of dietary salt, leads to hypertension and cardiac pathology in a susceptible strain of rats.Design and methods:In four experiments, borderline hypertensive rats, maintained on normal or high-salt diets, were exposed to 14–16 weeks aggregation in a colony housing or in larger breeder cages. Pulsatile blood pressure was measured once a week in unrestrained male rats by pressure telemetry. Direct carotid pressures of the aggregated rats and of control rats were measured before they were killed; at necropsy cardiac and adrenal weights and ventricular design were determined.Results:Despite continuous fighting, their weekly measured blood pressures remained stable; no differences in final carotid pressures between experimental and control rats were found. Rats from three aggregations showed significant increases in left and right ventricular and adrenal weights.Conclusion:No hypertension developed in any aggregation, although most of the rats showed signs of perceived stress (significantly reduced weight gain, enlarged adrenals and a large number of body wounds). Cardiac hypertrophy did ensue, possibly reflecting increased physical activity or intermittent increases in sympathetic activity, or both.
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