Peripherally administering the serotonin (5-HT) analogs, α-methyl-5-hydroxytryptamine (α-Me-5-HT) and 5-carboxamidotryptamine (5-CT), reduced milk consumption by food-deprived rats. 5-CT decreased milk intake 100-fold more potently than α-Me-5-HT (ID50's = .06 and 5.6$mUmol/kg, respectively). 5-CT also elicited drinking but α-Me-5-HT did not. The nonselective 5-HT antagonist, methysergide, blocked the anorectic actions of each agonist. By contrast, the 5-HT2antagonist, ketanserin, and the peripheral 5-HT22antagonist, xylamidine, only prevented anorexia due to α-Me-5-HT. These results suggest that stimulating either peripheral 5-HT2or peripheral 5-HT1-like receptors inhibits feeding in rats. 5-HT1-like sites may also mediate 5-HT-induced drinking.